Lab Presentation

Structural Biology of Protein-Nucleic Acid Complexes and Molecular Machines

Our research focuses on the 3D structure of proteins, nucleic acids and their complexes with the aim to further our understanding of several essential mechanisms in the cell. We use a number of molecular biology and structural biology techniques for our purposes, including X-ray diffraction—using synchrotron radiation, and electron microscopy. The final outcome is a detailed 3D view of the molecular structures of interest. This information, together with complementary molecular biology and biochemistry experiments, unveils how these proteins and molecular machines function.

We address the regulatory mechanisms of gene expression and DNA replication. In addition, we examine systems related to horizontal gene transfer that involve DNA translocation across cell membranes. We also study unique DNA structures, like DNA junctions, and novel drugs that target DNA and proteins.

ARF-transcription-factors

PhoB-promoters

Projects

  • Transcription regulation. Read more
  • DNA replication control. Read more
  • Horizontal gene transfer. Read more
  • DNA structure and drug-DNA interactions. Read more
  • DNA packaging in viruses.
  • Viral replication machinery.
  • Protein complexes, epigenetic regulation of gene expression and cancer.

Lab People

Miquel Coll Capella

Miquel Coll Capella

Research Professor CSIC

mcoll@ibmb.csic.es

Miquel Coll is the head of the Structural and Computational Biology Programme at the IRB Barcelona.

He obtained his degree in Biology in 1982 and his PhD in 1986 from the University of Barcelona. In 1986 he joined the laboratory of Prof. Alexander Rich at the Massachusetts Institute of Technology and worked on the structural analysis of DNA. In 1989 he moved to the Max-Planck-Institut in Munich and worked, as a postdoc with Prof. Robert Huber, in the structural analysis of a number of proteins. In 1990 he started a protein crystallography research group at the CSIC. In 1999-2000 he spent a sabbatical year at the Grenoble Outstation of the EMBL.

Miquel Coll is presently a CSIC Professor and has been Deputy Director of the Institut de Biologia Molecular de Barcelona from 2002 to 2006. In 2000 he was elected member of the European Molecular Biology Organization (EMBO).

Albert Canals Parera

Albert Canals Parera

Research associate

acpcri@ibmb.csic.es

Cristina Machón Sobrado

Cristina Machón Sobrado

Postdoctoral Researcher

cmscri@ibmb.csic.es

Olga Borisovna

Olga Borisovna

Postdoctoral Researcher

olga.borisovna@irbbarcelona.org

Montserrat Fabrega Ferrer

Montserrat Fabrega Ferrer

PhD Student

mffcri@ibmb.csic.es

Mireia Muriel Masanes

Mireia Muriel Masanes

PhD Student

mmmcri@ibmb.csic.es

Luis Daniel Toribio

Luis Daniel Toribio

PhD Student

luisdaniel.toribio@irbbarcelona.org

Jorge García

Jorge García

PhD Student

jorge.garcia@irbbarcelona.org

Rosa Perez Luque

Rosa Perez Luque

Research Technician

rplcri@ibmb.csic.es

Esther Ferrando Ferrer

Esther Ferrando Ferrer

Research Technician

effcri@ibmb.csic.es

Sara Muriel

Sara Muriel

PhD Student

sara.muriel@irbbarcelona.org

Selected Publications


Structural basis for DNA binding specificity by the auxin-dependent ARF transcription factors

Boer DR, Freire-Rios A, van den Berg WA, Saaki T, Manfield IW, Kepinski S, López-Vidrieo I, Franco-Zorrilla JM, de Vries SC, Solano R, Weijers D and Coll M.

Cell,2014. 156 (3), 577-89


Thread insertion of a bis(dipyridophenazine) diruthenium complex into the DNA double helix by the extrusion of AT base pairs and cross-linking of DNA duplexes

Boer DR, Wu L, Lincoln P and Coll M.

Angew Chem Int Edit, 2014. 53 (7), 1949-52


Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter

Rubio-Cosials A, Sidow JF, Jiménez-Menéndez N, Fernández-Millán P, Montoya J, Jacobs HT, Coll M, Bernadó P and Solà M.

Nat Struct Mol Biol, 2011. 18 (11), 1281-9


The structure of a transcription activation subcomplex reveals how σ(70) is recruited to PhoB promoters

Blanco AG, Canals A, Bernués J, Solà M and Coll M.

Embo J, 2011. 30 3776-3785


Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain

Nadal M, Mas PJ, Blanco AG, Arnan C, Solà M, Hart DJ and Coll M.

P Natl Acad Sci Usa, 2010. 107 (37), 16078-83


Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat

Jiménez-Menéndez N, Fernández-Millán P, Rubio-Cosials A, Arnan C, Montoya J, Jacobs HT, Bernadó P, Coll M, Usón I and Solà M.

Nat Struct Mol Biol, 2010. 17 (7), 891-3


Plasmid replication initiator RepB forms a hexamer reminiscent of ring helicases and has mobile nuclease domains

Boer DR, Ruíz-Masó JA, López-Blanco JR, Blanco AG, Vives-Llàcer M, Chacón P, Usón I, Gomis-Rüth FX, Espinosa M, Llorca O, del Solar G and Coll M.

Embo J, 2009. 28 (11), 1666-78


Molecular recognition of a three-way DNA junction by a metallosupramolecular helicate

Oleksy A, Blanco AG, Boer R, Usón I, Aymamí J, Rodger A, Hannon MJ and Coll M.

Angew Chem Int Edit, 2006. 45 (8), 1227-31


The structure of phage φ29 transcription regulator p4-DNA complex reveals an N-hook motif for DNA binding

Badia D, Camacho A, Pérez-Lago L, Escandón C, Salas M and Coll M

Mol Cell, 2006. 22 73-81


Recognition and processing of the origin of transfer DNA by conjugative relaxase TrwC

Guasch A, Lucas M, Moncalián G, Cabezas M, Pérez-Luque R, Gomis-Rüth FX, de la Cruz F and Coll M.

Nat Struct Mol Biol, 2003. 10 (12), 1002-10


The bacterial conjugation protein TrwB resembles ring helicases and F1-ATPase

Gomis-Rüth FX, Moncalián G, Pérez-Luque R, González A, Cabezón E, de la Cruz F and Coll M.

Nature, 2001409 (6820), 637-41


Crystal structure of a DNA Holliday junction

Ortiz-Lombardía M, González A, Eritja R, Aymamí J, Azorín F and Coll M.

Nat Struct Mol Biol, 1999. 6 (10), 913-7


All Publications


A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125.

Bijlmakers MJ, Teixeira JM, Boer R, Mayzel M, Puig-Sàrries P, Karlsson G, Coll M, Pons M, Crosas B.

Sci Rep. Jul 14;6:29232. (2016)


Conformational plasticity of RepB, the replication initiator protein of promiscuous streptococcal plasmid pMV158

Boer DR, Ruiz-Masó JA, Rueda M, Petoukhov MV, Machón C, Svergun DI, Orozco M, Del Solar G and Coll M.

Sci Rep, 6 20915 (2016)


Plasmid Rolling-Circle Replication

Ruiz-Masó JA, MachóN C, Bordanaba-Ruiseco L, Espinosa M, Coll M and Del Solar G.

Microbiol Spectrum, 3 (1), PLAS-0035 (2015)


The structure of the complex between α-tubulin, TBCE and TBCB reveals a tubulin dimer dissociation mechanism

Serna M, Carranza G, Martín-Benito J, Janowski R, Canals A, Coll M, Zabala JC and Valpuesta JM.

J Cell Sci, 128 (9), 1824-34 (2015)


The crystal structure and small-angle X-ray analysis of CsdL/TcdA reveal a new tRNA binding motif in the MoeB/E1 superfamily

López-Estepa M, Ardá A, Savko M, Round A, Shepard WE, Bruix M, Coll M, Fernández FJ, Jiménez-Barbero J and Vega MC.

PLoS One, 10 (4), e0118606 (2015)


Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli

Peña-Soler E, Fernandez FJ, López-Estepa M, Garces F, Richardson AJ, Quintana JF, Rudd KE, Coll M and Vega MC.

PLoS One, 9 (7), e102139 (2014)


Structural basis for DNA binding specificity by the auxin-dependent ARF transcription factors

Boer DR, Freire-Rios A, van den Berg WA, Saaki T, Manfield IW, Kepinski S, López-Vidrieo I, Franco-Zorrilla JM, de Vries SC, Solano R, Weijers D and Coll M.

Cell, 156 (3), 577-89 (2014)


Thread insertion of a bis(dipyridophenazine) diruthenium complex into the DNA double helix by the extrusion of AT base pairs and cross-linking of DNA duplexes

Boer DR, Wu L, Lincoln P and Coll M.

Angew Chem Int Edit, 53 (7), 1949-52 (2014)


New features of vault architecture and dynamics revealed by novel refinement using the deformable elastic network approach

Casañas A, Querol-Audí J, Guerra P, Pous J, Tanaka H, Tsukihara T, Verdaguer N and Fita I.

Acta Crystallogr D, 69 (Pt 6), 1054-61 (2013)


A novel family of soluble minimal scaffolds provides structural insight into the catalytic domains of integral membrane metallopeptidases

López-Pelegrín M, Cerdà-Costa N, Martínez-Jiménez F, Cintas-Pedrola A, Canals A, Peinado JR, Marti-Renom MA, López-Otín C, Arolas JL and Gomis-Rüth FX.

J Biol Chem, 288 (29), 21279-94 (2013)


Structure and non-structure of centrosomal proteins

Dos Santos HG, Abia D, Janowski R, Mortuza G, Bertero MG, Boutin M, Guarín N, Méndez-Giraldez R, Nuñez A, Pedrero JG, Redondo P, Sanz M, Speroni S, Teichert F, Bruix M, Carazo JM, Gonzalez C, Reina J, Valpuesta JM, Vernos I, Zabala JC, Montoya G, Coll M, Bastolla U and Serrano L.

PLoS One, 8 (5), e62633 (2013)


Functional properties and structural requirements of the plasmid pMV158-encoded MobM relaxase domain

Fernández-López C, Pluta R, Pérez-Luque R, Rodríguez-González L, Espinosa M, Coll M, Lorenzo-Díaz F and Boer DR.

J Bacteriol, 195 (13), 3000-8 (2013)


Nicking activity of the pMV158 MobM relaxase on cognate and heterologous origins of transfer

Fernández-López C, Lorenzo-Díaz F, Pérez-Luque R, Rodríguez-González L, Boer R, Lurz R, Bravo A, Coll M and Espinosa M.

Plasmid, 70 (1), 120-30 (2013)


σ70 and PhoB activator: getting a better grip

Canals A, Blanco AG and Coll M.

Transcription, 3 (4), 160-4 (2012)


PhoB transcriptional activator binds hierarchically to pho box promoters

Blanco AG, Canals A and Coll M.

Biol Chem, 393 (10), 1165-71 (2012)


Structure and mechanism of a cysteine sulfinate desulfinase engineered on the aspartate aminotransferase scaffold

Fernandez FJ, de Vries D, Peña-Soler E, Coll M, Christen P, Gehring H and Vega MC.

Bba-proteins Proteom, 1824 (2), 339-49 (2012)


Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter

Rubio-Cosials A, Sidow JF, Jiménez-Menéndez N, Fernández-Millán P, Montoya J, Jacobs HT, Coll M, Bernadó P and Solà M.

Nat Struct Mol Biol, 18 (11), 1281-9 (2011)


Site-directed mutagenesis of mouse glutathione transferase P1-1 unlocks masked cooperativity, introduces a novel mechanism for ‘ping pong’ kinetic behaviour, and provides further structural evidence for participation of a water molecule in proton abstraction from glutathione.

McManus G, Costa M, Canals A, Coll M and Mantle TJ.

Febs J, 278 (2), 273-81 (2011)


Picornavirus non-structural proteins as targets for new anti-virals with broad activity

Norder H, De Palma AM, Selisko B, Costenaro L, Papageorgiou N, Arnan C, Coutard B, Lantez V, De Lamballerie X, Baronti C, Solà M, Tan J, Neyts J, Canard B, Coll M, Gorbalenya AE and Hilgenfeld R.

Antiviral Res, 89 (3), 204-18 (2011)


The UlaG protein family defines novel structural and functional motifs grafted on an ancient RNase fold

Fernandez FJ, Garces F, Lopez-Estepa M, Aguilar J, Baldoma L, Coll M, Badia J and Vega MC.

Bmc Evol Biol, 11 (1), 273 (2011)


Structural basis for antiviral inhibition of the main protease, 3C, from human enterovirus 93

Costenaro L, Kaczmarska Z, Arnan C, Janowski R, Coutard B, Solà M, Gorbalenya AE, Norder H, Canard B and Coll M.

J Virol, 85 (20), 10764-73 (2011)


Structural insights into transcription complexes

Berger I, Blanco AG, Boelens R, Cavarelli J, Coll M, Folkers GE, Nie Y, Pogenberg V, Schultz P, Wilmanns M, Moras D and Poterszman A.

J Struct Biol, 175 (2), 135-46 (2011)


The MobM relaxase domain of plasmid pMV158: thermal stability and activity upon Mn2+ and specific DNA binding

Lorenzo-Díaz F, Dostál L, Coll M, Schildbach JF, Menéndez M and Espinosa M.

Nucleic Acids Res, 39 (10), 4315-29 (2011)


The structure of a transcription activation subcomplex reveals how σ(70) is recruited to PhoB promoters

Blanco AG, Canals A, Bernués J, Solà M and Coll M.

Embo J, 30 3776-3785 (2011)


Self-assembly of functionalizable two-component 3D DNA arrays through the induced formation of DNA three-way-junction branch points by supramolecular cylinders

Boer DR, Kerckhoffs JM, Parajo Y, Pascu M, Usón I, Lincoln P, Hannon MJ and Coll M.

Angew Chem Int Edit, 49 (13), 2336-9 (2010)


Molecular architecture of the Mn2+-dependent lactonase UlaG reveals an RNase-like metallo-beta-lactamase fold and a novel quaternary structure

Garces F, Fernández FJ, Montellà C, Penya-Soler E, Prohens R, Aguilar J, Baldomà L, Coll M, Badia J and Vega MC.

J Mol Biol, 398 (5), 715-29 (2010)


The structure of RNA-free Rho termination factor indicates a dynamic mechanism of transcript capture

Canals A, Usón I and Coll M.

J Mol Biol, 400 (1), 16-23 (2010)


Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain

Nadal M, Mas PJ, Blanco AG, Arnan C, Solà M, Hart DJ and Coll M.

P Natl Acad Sci Usa, 107 (37), 16078-83 (2010)


Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat

Jiménez-Menéndez N, Fernández-Millán P, Rubio-Cosials A, Arnan C, Montoya J, Jacobs HT, Bernadó P, Coll M, Usón I and Solà M.

Nat Struct Mol Biol, 17 (7), 891-3 (2010)


Mechanical network in titin immunoglobulin from force distribution analysis

Stacklies W, Vega MC, Wilmanns M and Gräter F.

Plos Comput Biol, 5 (3), e1000306 (2009)


Plasmid replication initiator RepB forms a hexamer reminiscent of ring helicases and has mobile nuclease domains

Boer DR, Ruíz-Masó JA, López-Blanco JR, Blanco AG, Vives-Llàcer M, Chacón P, Usón I, Gomis-Rüth FX, Espinosa M, Llorca O, del Solar G and Coll M.

Embo J, 28 (11), 1666-78 (2009)


DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes

Boer DR, Canals A and Coll M.

Dalton T (3), 399-414 (2009)


Cloning, expression, purification and crystallization of the Rho transcription termination factor from Thermotoga maritima

Canals A and Coll M.

Protein Expres Purif, 65 (2), 174-8 (2009)


Molecular machinery for DNA translocation in bacterial conjugation

Russi S, Boer R and Coll M

In Plasmids: Current Research and Future Trends, Horizon Scientific Press,  183-13 (2008)


The VIZIER project: preparedness against pathogenic RNA viruses

Coutard B, Gorbalenya AE, Snijder EJ, Leontovich AM, Poupon A, De Lamballerie X, Charrel R, Gould EA, Gunther S, Norder H, Klempa B, Bourhy H, Rohayem J, L’hermite E, Nordlund P, Stuart DI, Owens RJ, Grimes JM, Tucker PA, Bolognesi M, Mattevi A, Coll

Antivir Res, 78 (1), 37-46 (2008)


Quaternary structural transitions in the DeoR-type repressor UlaR control transcriptional readout from the L-ascorbate utilization regulon in Escherichia coli

Garces F, Fernández FJ, Gómez AM, Pérez-Luque R, Campos E, Prohens R, Aguilar J, Baldomà L, Coll M, Badía J and Vega MC

Biochemistry, 47 (44), 11424-33 (2008)


Overproduction, crystallization and preliminary X-ray analysis of the putative L-ascorbate-6-phosphate lactonase UlaG from Escherichia coli

Garces F, Fernández FJ, Pérez-Luque R, Aguilar J, Baldomà L, Coll M, Badía J and Vega MC.

Acta Crystallogr F, 64 (Pt 1), 36-8 (2008)


The X-ray crystal structures of two constitutively active mutants of the Escherichia coli PhoB receiver domain give insights into activation

Arribas-Bosacoma R, Kim SK, Ferrer-Orta C, Blanco AG, Pereira PJB, Gomis-Rüth X, Wanner BL, Coll M and Solà M

J Mol Biol, 366 626-41 (2007)


Molecular recognition of a three-way DNA junction by a metallosupramolecular helicate

Oleksy A, Blanco AG, Boer R, Usón I, Aymamí J, Rodger A, Hannon MJ and Coll M.

Angew Chem Int Edit, 45 (8), 1227-31 (2006)


Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens

Fogg MJ, Alzari P, Bahar M, Bertini I, Betton JM, Burmeister WP, Cambillau C, Canard B, Carrondo M, Coll M, Daenke S, Dym O, Egloff MP, Enguita FJ, Geerlof A, Haouz A, Jones TA, Ma Q, Manicka SN, Migliardi M, Nordlund P, Owens RJ, Peleg Y, Schneider

Acta Crystallogr D, 62 1196-07 (2006)


Cut and move: DNA processing in bacterial conjugation

Gomis-Rüth FX and Coll M

Curr Opin Struc Biol, 16 744-52 (2006)


The cofactor-induced pre-active conformation in PhoB

Solà M, Drew DL, Blanco AG, Gomis-Rüth FX and Coll M

Acta Crystallogr D, 62 1046-57 (2006)


Unveiling the molecular mechanism of a conjugative relaxase: The structure of TrwC complexed with a 27-mer DNA comprising the recognition hairpin and the cleavage site

Boer R, Russi S, Guasch A, Lucas M, Blanco AG, Pérez-Luque R, Coll M and de la Cruz F

J Mol Biol, 358 857-69 (2006)


The structure of phage φ29 transcription regulator p4-DNA complex reveals an N-hook motif for DNA binding

Badia D, Camacho A, Pérez-Lago L, Escandón C, Salas M and Coll M

Mol Cell, 22 73-81 (2006)


The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs.

Canals A, Purciolas M, Aymamí J, Coll M.

Acta Crystallogr D Biol Crystallogr., Pt 7 (61), 1009-1012 (2005)


Crystal structure of an iron-dependent group III dehydrogenase that interconverts L-lactaldehyde and L-1,2-propanediol in Escherichia coli

Montella C, Bellsolell L, Pérez-Luque R, Badía J, Baldoma L, Coll M, Aguilar J.

J Bacteriol., 14 (187), 4957-4966 (2005)


Recognition and processing of the origin of transfer DNA by conjugative relaxase TrwC

Guasch A, Lucas M, Moncalián G, Cabezas M, Pérez-Luque R, Gomis-Rüth FX, de la Cruz F and Coll M.

Nat Struct Mol Biol, 10 (12), 1002-10 (2003)


Conjugative plasmid protein TrwB, an integral membrane type IV secretion system coupling protein. Detailed structural features and mapping of the active site cleft

Gomis-Rüth FX, Moncalían G, de la Cruz F, Coll M.

J Biol Chem., 9 (277), 7556-7566 (2002)


Structure of the DNA-bound T-box domain of human TBX3, a transcription factor responsible for ulnar-mammary syndrome.

Coll M, Seidman JG, Müller CW.

Structure, 3 (10), 343-356 (2002)


Crystallization and preliminary X-ray analysis of the antimalarial and cytotoxic alkaloid cryptolepine complexed with the DNA fragment d(CCTAGG)2.

Lisgarten JN, Pous J, Coll M, Wright CW, Aymami J.

Acta Crystallogr D Biol Crystallogr., Pt 2 (58), 312-313 (2002)


Crystallization and preliminary X-ray analysis of the DNA decamers d(CCGGATCCGG) and d(CCGGCGCCGG)

Aymami J, Pous J, Lisgarten JN, Coll M.

Acta Crystallogr D Biol Crystallogr., Pt 2 (58), 310-311 (2002)


Detailed architecture of a DNA translocating machine: the high-resolution structure of the bacteriophage phi29 connector particle.

Guasch A, Pous J, Ibarra B, Gomis-Rüth FX, Valpuesta JM, Sousa N, Carrascosa JL, Coll M.

J Mol Biol., 4 (315), 663-676 (2002)


The antimalarial and cytotoxic drug cryptolepineintercalates into DNA at cytosine-cytosine sites

Lisgarten JN, Coll M, Portugal J, Wright CW & Aymamí J

Nature Structural Biology,  (9), 57-60 (2002)


Trypanosoma cruzi macrophage infectivity potentiator has arotamase core and a highly exposed α-helix

Pereira PJB, Vega MC, González-Rey E, Fernández-Carazo R, Macedo-Ribeiro S, Gomis-Rüth FX, González A & Coll M

EMBO reports (3), 88-94 (2002)


Tandem DNA recognition by PhoB, a two-component signal transduction transcriptional activator

Blanco AG, Sola M, Gomis-Rüth FX & Coll M

Structure (10), 1-20 (2002)


The bacterial conjugation protein TrwB resembles ring helicases and F1-ATPase

Gomis-Rüth FX, Moncalián G, Pérez-Luque R, González A, Cabezón E, de la Cruz F and Coll M.

Nature, 409 (6820), 637-41 (2001)


Review: postchaperonin tubulin folding cofactors and their role in microtubule dynamics

Lopez-Fanarraga M, Avila J, Guasch A, Coll M, Zabala JC.

J Struct Biol., 2 (135), 219-229 (2001)


The structure of an engineered domain-swapped ribonuclease dimer and its implications for the evolution of proteins toward oligomerization.

Canals A, Pous J, Guasch A, Benito A, Ribó M, Vilanova M, Coll M.

Structure, 10 (9), 967-976 (2001)


Structure of TrwB, a gatekeeper in bacterial conjugation

Gomis-Rüth FX, Coll M.

Int J Biochem Cell Biol., 9 (33), 839-843 (2001)


Plasmid transcriptional repressor CopG oligomerises to render helical superstructures unbound and in complexes with oligonucleotides

Costa M, Solà M, del Solar G, Eritja R, Hernández-Arriaga AM, Espinosa M, Gomis-Rüth FX, Coll M.

J Mol Biol., 2 (310), 403-417 (2001)


The crystal structure of the inhibitor-complexed carboxypeptidase D domain II and the modeling of regulatory carboxypeptidases

Aloy P, Companys V, Vendrell J, Aviles FX, Fricker LD, Coll M, Gomis-Rüth FX.

J Biol Chem., 19 (276), 16177-16184 (2001)


Solving a 300-kDa multimeric protein by low-resolution MAD phasing and averaging/phase extension

Gomis-Rüth FX, Coll M.

Acta Crystallogr D Biol Crystallogr., Pt 6 (57), 489-505 (2001)


Three-dimensional structure of human biliverdin-IXβ reductase, an early fetal bilirubin-IXβ producing enzyme

Pereira PJ, Macedo-Ribeiro S, Párraga A, Pérez-Luque R, Cunningham O, Darcy K, Mantle TJ, Coll M.

Nat Struct Biol, 3 (8), 215-220 (2001)


Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution.

Pous J, Mallorquí-Fernández G, Peracaula R, Terzyan SS, Futami J, Tada H, Yamada H, Seno M, de Llorens R, Gomis-Rüth FX, Coll M.

Acta Crystallogr D Biol Crystallogr, Pt 4 (57), 498-505 (2001)


Structure of human biliverdin-IXβ reductase, an earlyfetal bilirubin-IXβ producing enzyme

Pereira PJ, Macedo-Ribeiro S, Párraga A, Pérez-Luque R, Cunningham O, Darcy K, Mantle TJ and Coll M

Nat Struct Biol, 3 (8), 215-220 (2001)


Crystal structure of a DNA Holliday junction

Ortiz-Lombardía M, González A, Eritja R, Aymamí J, Azorín F and Coll M.

Nat Struct Mol Biol, 6 (10), 913-7 (1999)


Project Funding

Ongoing Projects


Reference: 2014 MDM-2014-0435
Title: Unidad de Excelencia María de Maeztu. Unidad Departamento de Biología Estructural
Period: 01/07/15 – 30/06/19.

PI: M. Coll.
Agency: Ministerio de Economía y Competitividad.


Reference: BFU2014-53550-P
Title: Structure of DNA-binding proteins and complexes.
Period: 01/01/2015-31/12/2017.

IP: M. Coll.
Agency: Ministerio de Economía y Competitividad.


Reference: Ajuts a Grups de Recerca Consolidats 2014 SGR.
Title: Biologia estructural de complexos de proteïnes i àcids nucleics, i màquines moleculars.
Period: 2014-2016.

PI: M.Coll.

Agency: DIUE, Generalitat de Catalunya.


Project Funding

Concluded Projects


Reference: BioMedTec 2013
Title: Validation of a new antiviral drug class against herpesvirus.
Period: 1/9/2013 – 31/8/2014.

IP: M. Coll.
Agency: La Caixa-IRB.


Reference: Proyecto Plan Nacional de I+D+I BFU2011-22588

Title: Structure of DNA binding proteins and complexes (PRODNA).

Period: 2012-2014.

PI: M.Coll.

Agency: Ministerio de Educación y Ciencia.


Reference: FP7 Collaborative Project, Large Scale Integrating Project,GA 260644.

Title: Small-molecule inhibitor leads versus emerging and neglected RNA viruses (SILVER).
Period: 2010-2014.

PI: M.Coll.

Agency: European Commission


Reference: Ajuts a Grups de Investigació Consolidats 2009 SGR 1309.

Title: Grupo de cristalografía de proteínas.

Period: 2009-2012. PI: M.Coll.

Agency: DIUE, Generalitat de Catalunya.


Reference: Proyecto Plan Nacional de I+D+I BFU2008-02372/BMC

Title: Structure of DNA binding proteins and complexes (PRODNA).

Period: 2009-2011.

PI: M.Coll.

Agency: Ministerio de Educación y Ciencia.


Reference: Proyecto PETRI PET2007_0319_03

Title: Caracterización estructural de inhibidores de metiltransferasas.

Period: 2008 – 2010.

PI: M.Coll.

Agency: Ministerio de Educación y Ciencia.


Reference: Acción complementaria de investigación BFU2007-29798-E

Title: Ayuda Complementaria al proyecto ESPINE2-COMPLEJOS: Del receptor al gen: Estructuras de complejos de vías de señalización, uniendo inmunología, neurobiología y cancer.

Period: 2008 –2009.

PI: M.Coll.

Agency: Ministerio de Educación y Ciencia.


Reference: Proyecto Consolider. CSD2006-23.

Title: Centrosoma_3D: Hacia la comprensión estructural y funcional del centrosoma.

Period: 2006-2011.

PI: M.Coll.

Agency: Ministerio de Educación y Ciencia.


Reference: Acción complementaria de investigación BFU2005-24123-E

Title: Ayuda complementaria al proyecto: Una aproximación multidisciplinaria para determinar las estructuras de los complejos proteicos en un organismo modelo.

Period: 2006 – 2010.

PI: M.Coll.

Agency: Ministerio de Educación y Ciencia.


Reference: Acción complementaria de investigación BFU2005-24122-E

Title: Ayuda complementaria al proyecto: Genómica estructural comparativa para enzimas víricos

Period: 2006 – 2010.

PI: M.Coll.

Agency: Ministerio de Educación y Ciencia.


Reference: EU Integrated Project LSHG-2006-031220

Title: SPINE2-Complexes: From Receptor to Gene: Structures of complexes from signalling pathways linking, immunology, neurobiology and cancer (Spine2-Complexes).

Period: 2006-2010.

PI: M.Coll.

Agency: European Commission.


Reference: Proyecto Integrado VI PM LSHG-CT-2005-512028

Title: A Multidisciplinary Approach to Determine the Structures of Protein Complexes in a Model Organism (3D-REPERTOIRE).

Period: 2005-2009.

PI: M.Coll.

Agency: European Commission.


Reference: Proyecto Plan Nacional de I+D+I BFU2005-06758/BMC

Title: Estructura de proteínas y complejos de unión al DNA

Period: 2005-2008.

PI: M.Coll.

Agency: Ministerio de Educación y Ciencia.


Reference: Ayudas a Grupos de Investigación Consolidados 2005SGR-00280.

Title: Grupo de cristalografía de proteínas.

Period: 2005-2008.

PI: M.Coll.

Agency: CIRIT, Generalitat de Catalunya.


Reference: Proyecto Fundació La Marató de TV3 052810.

Title: Epigenetic Chromatin Regulation Proteins as targets in Anticancer Strategy

Period: 2005 –2008.

PI: M.Coll.

Agency: Fundació La Marató de TV3.


Reference: EU Integrated Project VI PM LSHG-CT-2004-511960

Title: Integrated structural genomics of viral enzymes involved in replication (VIZIER).

Period: 2004-2008.

PI: M.Coll.

Agency: European Comission


Reference: Proyecto Integrado GEN2003-20642. Acción estrategica de genómica y proteómica

Title: Genómica estructural: aplicación a proteínas y complejos proteicos relacionados con el cáncer.

Period: 2004-2007.

PI: M.Coll.

Agency: Ministerio de Ciencia y Tecnología.


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